LiveRank. For example, microbiomes associated with obesity have been distinguished by different ratios of bacterial phyla, which encompass a staggering range of diversity. Whenever a study links a microbiome to a disease, wise critics should ask whether other contributors to disease are considered, compared and reported. What is more, many of the ongoing attempts to develop new vaccines by identifying and targeting virulence factors have so far proved fruitless. The Nature Research Microbiology Community provides a forum for the sharing and discussion of ideas and opinions about microbiology. Can experiments detect differences that matter? A separate question is raised when distinct microbiomes can be identified and associated with diseases or other conditions. Nature Microbiology is an online-only peer reviewed scientific journal established in 2016, published monthly by the Nature Publishing Group.The chief editor is Andrew Jermy who is part of an in-house team of editors. This explanation fits the data, but the reverse causality — the potential for poor health to alter the gut microbiome — was not explored. USA 111, 5439–5444 (2014). A 2012 article comparing the gut microbiomes of old people living in care homes with those of old people living in the community found distinct microbiomes that correlated with multiple scores of frailty5. Over the past five years, studies have linked our microbial settlers to conditions as diverse as autism, cancer and diabetes. This could explain why in the 1890s, when microbiologist Robert Koch injected people who had tuberculosis with an extract that he had produced from culturing the bacteria in the laboratory, many of them died. Nature Microbiology. Explorations of how the microscopic communities that inhabit the human body might contribute to health or disease have moved from obscure to ubiquitous. Researchers deleted or inactivated genes in search of those encoding 'virulence factors', molecules thought to enable a microbe to invade and inhabit a host and cause disease. In the decades after the word pathogen was coined, it became clear that many 'non-pathogens' can be harmful in some people. Last day 1 week 1 month all. As excitement over the microbiome has filtered beyond academic circles, the potential mischief wrought by misunderstanding encompasses journalists, funding bodies and the public. Journal info (provided by editor) The editor of Nature Microbiology has not yet provided information for this page. With how-to instructions proliferating online, desperate patients must be warned not to attempt these risky procedures on themselves. Nature Genet. ... Our award-winning show features highlights from the week's edition of Nature, ... and in-depth commentary and analysis from journalists around the world. The Nature Research Microbiology Community provides a forum for the sharing and discussion of ideas and opinions about microbiology. AGORA, HINARI, OARE, INASP, CrossRef and COUNTER. Opin. LiveRank. At Springer Nature, we are committed to raising the quality of academic research across Microbiology. Funding agencies must not let their priorities be distorted by the buzz around the field, but look dispassionately at the data. Mice and their microbiomes are also adapted to a rather different niche from humans, so results may not be generalizable. But painstaking further work dampened early excitement. The need for continued access to research and learning has never been more important. Proc. What matters in science — and why — free in your inbox every weekday. This excitement has infected the public imagination. Likewise, it is the massive activation of white blood cells triggered by certain strains of Staphylococcus and Streptococcus bacteria that can lead to toxic-shock syndrome. Last day 1 week 1 month all. Despite decades of searching, no classical virulence factor suitable for vaccine development has been identified for the tuberculosis bacillus or malaria parasite. This prompted microbiologists to use qualifiers, mostly from the 1960s onwards, to define microbes according to their state in the host organism. Nature Microbiology is concerned with all aspects of the broad field of microbiology, and all types of microorganism, including bacteria, viruses, eukaryotes and archaea. For instance, A. fumigatus can cause severe pulmonary disease in people with leukaemia; some strains of E. coli can cause diarrhoea and vomiting, and in one out of three people, Staphylococcus aureus behaves more like a commensal, inhabiting nasal cavities without causing harm. © 2019 Macmillan Publishers Limited, part of Springer Nature. Faecal transplants have been proposed — some more sensible than others — for conditions ranging from diabetes to Alzheimer's disease. Yet a microbe cannot cause disease without a host. AGORA, HINARI, OARE, INASP, CrossRef and COUNTER. Disease is as much about the host as it is the infectious agent — the focus on microbes is hindering research into treatments, say Arturo Casadevall and Liise-anne Pirofski. © 2019 Macmillan Publishers Limited, part of Springer Nature. Previous 'omics' fields have faltered after murky work slowed progress2. Casadevall, A. Huh, D. et al. In the past three or four years, studies have advanced from characterizing a broad community of mainly unculturable microbes to identifying functional elements, individual taxa or particular properties. Ridaura, V. K. et al. Similarly, a vaccine that makes the polysaccharide capsule of bacteria vulnerable to attack from white blood cells by prompting lymphocytes to produce antibodies against it has virtually eradicated H. influenzae type B, a major cause of meningitis before the 1980s. 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